Standard Treatment For high grade stromal sarcomas, standard therapy is a hysterectomy , removal of the tubes and ovaries, selective pelvic and aortic node sampling and washings from the abdominal cavity to look for malignant cells.
For early-stage cancer, postoperative pelvic radiation therapy (total dose of 4,000 to 5,000 cGy given in divided doses, five days a week for five weeks) is recommended because it decreases the chance of a pelvic recurrence .
Adjuvant chemotherapy is sometimes given, but it should be considered experimental.
Investigational
• Since pelvic and distant recurrences are common and the prognosis of this malignancy is poor, many
gynecologic oncologists and medical oncologists recommend adjuvant chemotherapy even though it has not yet
been shown to be effective.
• Adriamycin in combination with DTIC or Cytoxan has been shown to be no more effective than Adriamycin
alone.
• Vincristine and Cytoxan in combination with actinomycin-D or Adriamycin with or without DTIC may be
somewhat effective.
• Mitoxantrone , a drug similar to Adriamycin, and ifosfamide are being studied.
